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Mean corpuscular volume
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Mean corpuscular volume : ウィキペディア英語版
Mean corpuscular volume
The mean corpuscular volume, or mean cell volume (MCV), is a measure of the average volume of a red blood corpuscle (or red blood cell). The measure is attained by multiplying a volume of blood by the proportion of blood that is cellular (the hematocrit (or haematocrit)), and dividing that product by the number of erythrocytes (red blood cells) in that volume. The mean corpuscular volume is a part of a standard complete blood count. In a laboratory test that computes MCV, erythrocytes are compacted during centrifugation.
In patients with anemia, it is the MCV measurement that allows classification as either a microcytic anemia (MCV below normal range), normocytic anemia (MCV within normal range) or macrocytic anemia (MCV above normal range). Normocytic anemia is usually deemed so because the bone marrow has not yet responded with a change in cell volume. It occurs occasionally in acute conditions, namely blood loss and hemolysis.
If the MCV was determined by automated equipment, the result can be compared to RBC morphology on a peripheral blood smear. Any deviation would usually be indicative of either faulty equipment or technician error, although there are some conditions that present with high MCV without megaloblastic cells.
For further specification, it can be used to calculate red blood cell distribution width.
==Calculation==

To calculate MCV, the hematocrit (Hct) is divided by the concentration of RBCs (())
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Normally, MCV is expressed in femtoliters (fL, or 10−15L), and () is the quantity expressed in millions per microliter (106 / μL). The normal range for MCV is 80–100 fL.
For example, if the Hct = 42.5% and () = 4.58 million per microliter (4,580,000/μL), then
\textit = \frac \, L = 92.8 \, \textit
Use of volume-sensitive automated blood cell counters, such as the Coulter counter. In this type of apparatus, the red cells pass one-by-one through a small aperture and generate a signal directly proportional to their volume.
Other automated counters measure red blood cell volume by means of techniques that measure refracted, diffracted, or scattered light.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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